Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic detail, thus providing the platform for functional interpretation and therapeutic design. Structural Virology is a new monograph with contributions from experts in the field of structural biology and virology. It is aimed at biomedical scientists involved in basic and/or applied research but also provides up-to-date reference material for students entering the field. The book covers a wide range of topicsand is split into three sections. The first discusses methodologies used in structural virology, including sample production and purification, negative-stain and cryo-electron microscopy, X-ray crystallography and mass spectroscopy. The second discusses the role of virus capsid structure in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The third discusses therapeutic strategies based on virus capsid structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development
- ISBN: 978-0-85404-171-8
- Editorial: Royal Society of Chemistry
- Encuadernacion: Cartoné
- Páginas: 299
- Fecha Publicación: 01/11/2010
- Nº Volúmenes: 1
- Idioma: Inglés