Control of innate and adaptive immune responses during infectious diseases

Upon infection the host needs to mount vigorous immune response against pathogen in order to successfully control its replication. However, once the infectious agent is controlled or eliminated, host cells need to signal the immune system to slow or cease its activities. While vast knowledge has been accumulated through the years on the mechanisms involved in the initiation and effectorphases of the immune responses, the pathways triggered in order to modulate or end innate and acquired immunity are becoming more evident as evidence for its relevance comes to surface. Due to its biological power, evidence has surfaced indicating that eventually pathogens may take advantage of such regulatorypathways in order to escape effector mechanisms and progress to persistence. This book will discuss several cellular pathways involved in controlling immune response in the context of infectious diseases, their biological consequences and potential 'hijack' of these pathways for the benefit of pathogen leadingtowards pathogen persistence as opposed to clearance. Explores immune regulatory mechanisms that take place during some of the most relevant infectious diseases worldwide. Provides a wide spectrum understanding of the immune system modulates ongoing responses to prevent host pathology. Full-color figures illustrate complex ideas. INDICE: Resolution of inflammation during Toxoplasma gondii infection. Mechanisms of host protection and pathogen evasion of immune response during tuberculosis. NKT cell activation during (microbial) infection. Regulation of innate immunity during Trypanosoma cruzi infection. B cell-mediated regulation of immunity during Leishmania infection. Control of the Host Response to Histoplasma capsulatum. Modulation of T-cell mediated immunity by cytomegalovirus. T cell responses during Human Immunodeficiency Virus (HIV)-1 infection.

• ISBN: 978-1-4614-0483-5
• Editorial: Springer New York
• Encuadernacion: Cartoné
• Páginas: 140
• Fecha Publicación: 28/10/2011
• Nº Volúmenes: 1
• Idioma: Inglés