Cancer Treatment and the Ovary: Clinical and Laboratory Analysis of Ovarian Toxicity

Cancer Treatment and the Ovary: Clinical and Laboratory Analysis of Ovarian Toxicity provides the reader with a basic understanding on how the ovary is adversely impacted by cancer treatment, an essential foundational knowledge for this rapidly-developing field. The book describes both the clinical and laboratory approaches to discovering the potentially adverse effects of cancer treatment on the ovary, also laying out possible preventative approaches and future directions for the field. Clinicians working in the field of reproductive biology and oncology will find an essential reference that provides the necessary tools to assess the reproductive toxicological effects of cancer treatments. Brings together an international group of experts to address the current state of the science of ovarian toxicity caused by cancer treatment Provides scientific, clinical, and preclinical approaches to assessing this toxicityDescribes current techniques and future strategies to protect the ovaryIdeal reference for the further study of ovarian toxicity, oncofertility, cancer treatment, and reproductive toxicology INDICE: Section 1: Clinical 1. Basic ovarian function and models underpinning the ovarian lifespan. 2. Relevant cancer diagnoses, commonly-used chemotherapy agents, and their biochemical mechanisms of action. 3. Clinical assessment of damage to ovarian function and lifespan: current and future biomarkers. 4. Current understanding of clinical data on ovarian toxicity from chemotherapy. 5. Radiotherapy and the ovary. Section 2: Laboratory models 6. In vivo models of ovarian toxicity: rodent and primate (possibly 2 chapters). 7. In vitro models of ovarian toxicity: cell lines, rodent, primate (human and non-human) ovarian tissue. Section 3: Strategies to protect the ovary 8. Ovarian tissue cryopreservation for fertility preservation 9. Current clinical approaches to protecting the ovary: GnRH analogues, COCP. 10. Pre-clinical approaches: Imatinib, PARP inhibitors and others.

• ISBN: 978-0-12-801591-9
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 112
• Fecha Publicación: 01/09/2015
• Nº Volúmenes: 1
• Idioma: Inglés