Cellular Respiration and Carcinogenesis presents leading experts in the fieldas it informs the reader about both basic and recent research in the field ofcellular respiration and the effects of its dysfunction, alteration or attenuation on the development of cancer. This masterfully complied text offers the reader a fundamental understanding about how oxygen sensing and/or availability, programmed cell death, immune recognition and response and glucose metabolism are intimately linked with the two major mechanism or pathways of cellular respiration; oxidative phosphorylation and glycolysis. The editors and contributing authors proficiently and unequivocally address the effects of dysfunction of the mitochondrial oxidative phosphorylation/glycolysis (cellular respiration) mechanisms and pathways on the development of cancer. Provides first glimpse into cutting-edge research Masterfully opens a new dialogue in regards to the Warburg hypothesis INDICE: Foreword.- Oxidative phosphorylation and cancer: the ongoing Warburg hypothesis.- The electron transport chain and carcinogenesis.- Respiratory control of redox-signaling and cancer.- Cellular respiration and dedifferentiation.- Cellular adaptations to OXPHOS defects in cancer.- Regulation of glucose and energy metabolism in cancer cells by hypoxia inducible factor 1.- The role of glycolysis in cellular immortalization.- Metabolic modulation of carcinogenesis.- Mitochondrial DNA mutations in tumors.- Cellular respiration and tumor suppressor genes.- Uncoupling cellular respiration: a link to cancer cell metabolism and immune privilege.- How cancer cells escape death.
- ISBN: 978-1-934115-07-7
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 255
- Fecha Publicación: 01/11/2008
- Nº Volúmenes: 1
- Idioma: Inglés