This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise INDICE: 1. Metal ion physiology: Mechanistic approach Svetlana Lutsenko 2. Transferrin mediated iron uptake Anne B. Mason 3. Structure-function of siderophore-iron transporters Isabelle J. Schalk 4. Iron transport machinery of human cells: players and their interactions Caroline A. Enns 5. Mechanism of copper uptake in mammalian cells Vinzenz Unger and Jack H. Kaplan 6. Heavy metal transport P-type ATPases Amy C. Rosenzweig and Jose Argüello 7. CUS periplasmic Cu+ efflux system Ninian J. Blackburn and Megan McEvoy 8. Molecular architecture and function of ZnT transporters Taiho Kambe 9. Structure-function of ZIP transporters Robert E. Dempski 10. Nramp family of transporters Mathieu F. Cellier 11. Plant YSL metal transporters Elsbeth Walker and Sarah S. Conte 12. Pathways of arsenic uptake and detoxification Barry P. Rosen 13. Mechanisms of heme transport and trafficking Angela Wilks 14. Mechanisms of Mg2+ and Co2+ transport Said Eshaghi
- ISBN: 978-0-12-394390-3
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 456
- Fecha Publicación: 14/12/2012
- Nº Volúmenes: 1
- Idioma: Inglés