Muscle aging, inclusion-body myositis and myopathies

INDICE: Part 1 Muscle Ageing 1 Ageing of the human neuromuscular system: Pathological aspects (W. King Engel and Valerie Askanas). 2 Aging of the human neuromuscular system: Clinical considerations (W. King Engel and Valerie Askanas). 3 Aging of the human neuromuscular system: Patient vignettes (W. King Engel, Shalini Mahajan, Valerie Askanas). 4 Mitochondrial changes in ageing with particular reference to muscle, and possible clinical consequences (Salvatore DiMauro, Eric Schon, Michio Hirano). 5 Protein degradation in ageing cells and mitochondria: relevance to the neuromuscular system (Jenny Ngo and Kelvin Davies). 6 Human muscle protein metabolism in relation to exercise and aging: potential therapeutic applications Micah J. Drummond, Blake B. Rasmussen). Part 2 Sporadic Inclusion-Body Myositis (s-IBM) 7 Pathogenesis of sporadic inclusion-body myositis (Valerie Askanas, W. King Engel, Anna Nogalska). 8 Inflammatory and autoimmune features of inclusion-body myositis (Marinos Dalakas). 9 Clinical symptoms, physical findings and diagnostic investigations (Frank Mastaglia). 10 Pathologic diagnostic criteria of s-IBM and h-IBMs muscle biopsies (Valerie Askanas and W. King Engel). Part 3 Hereditary Inclusion-Body Myopathies (h-IBM) 11Function and mutations of the GNE gene leading to DMRV/h-IBM, animal models, and potential treatments (May Malicdan, Satoru Noguchi, Ichizo Nishino).12 Clinical and ethnic spectrum, laboratory data and epidemiology of h-IBM due to GNE mutations (Zohar Argov, Ishizo Nishino, Ikiyo Nonaka). 13s disease and fronto-temporal dementia; experimental models of VCP mutations, and potential treatments (Virginia Kimonis). 16 Animal models of h-IBM due to VCP mutation(Nisha M. Badders and Paul Taylor).

• ISBN: 978-1-4051-9646-8
• Editorial: Wiley-Blackwell
• Encuadernacion: Cartoné
• Páginas: 252
• Fecha Publicación: 20/01/2012
• Nº Volúmenes: 1
• Idioma: Inglés