Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumor Biology

Although considerable efforts have been conducted to diagnose, improve, and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. One of the best hopes for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase our current understanding of tumour biology, and will allow nanomaterials to be used for targeting and imaging both in vitro and in vivo experimental models. Owing to their intrinsic physicochemical characteristics, nanostructures (NS) are valuable tools that have received much attention in nanoimaging. Consequently, rationally designed NS have been successfully employed in cancer imaging for targeting cancer-specific or cancer-associated molecules and pathways. Targeted Cancer Imaging: Design and Synthesis of Nanoplatofrms based on Tumour Biology reviews and categorizes imaging and targeting approaches according to cancer type - highlighting some new and safe approaches that involve membrane-coated nanoparticles, tumour cell-derived extracellular vesicles, circulating tumour cells, cell-free DNAs, and cancer stem cells - with the goal of pointing the way to developing precise targeting and multifunctional nanotechnology-based imaging probes in the future. This book is highly multidisciplinary, bridging the knowledge gap between tumour biology, nanotechnology, and diagnostic imaging, making it suitable for researchers ranging from oncology to bioengineering. Gives understanding of cancer biology appropriate for students and researchers in engineering and nanotechnologyDemonstrates cancer targeting strategies of multifunctional nanotechnology-based imaging probesShows how to design, synthesize and apply cancer imaging nanostructures INDICE: 1. Introduction 2. Passive Targeting 3. Active targeting 4. Tumor-Specific Imaging Probes in Clinical Trials 5. Challenges and Future Directions

• ISBN: 978-0-12-824513-2
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 200
• Fecha Publicación: 01/06/2021
• Nº Volúmenes: 1
• Idioma: Inglés