Animal Models in Cancer Drug Discovery covers recent developments in tumor model systems for translational cancer research. Virtually all types of existing and emerging tumor models in use by the research community are discussed. Areas covered include the latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. Chapters on larger animal models, canine models and their use in pre-IND development make this a unique volume. In addition, sections on breeding methodologies and handling and assessment procedures make this book a must read. This book will be a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations and knowledge seekers at all levels of the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid system, humanized and other models in modern biology paradigmsCovers the use of these models in personalized medicine, immunotherapy, toxicology, Pre-IN assessments and related drug development arenasPresents protocols, procedures and a comprehensive glossary to help newer readers understand technical terms and specialized nomenclature INDICE: 1. Cancer Cachexia models 2. Ovarian Cancer models 3. Role of animal research in human malignancies 4. Imaging tools to enhance animal tumor models for cancer research and drug discover 5. Genetic tumor models of pancreatic cancer 6. Obesity models of cancer 7. Primary Brain Tumor models 8. Systemic model brain penetrance analysis 9. A guide to tumor model assessment methodologies in cancer drug discovery 10. Mouse Models of Pancreatic Cancer: An Ever-emerging Arm of Cancer Drug Discovery 11. Murine Models of Gastrointestinal Cancers in Drug Research and Development 12. Pre-clinical Animal Tumor Models to Study Prevention of Colon Cancer Recurrence by Curcumin 13. Role of 3D tissue engineering models for human cancer and drug development 14. Drug Development Using Pancreatic and Lung Organoid Models 15. Leveraging Dogs with Spontaneous Cancer to Advance Drug Development 16. PET imaging in Tumor Models 17. Melanoma Animal Tumor Models 18. Animal Mouse Models of Acute Myeloid Leukemia
- ISBN: 978-0-12-814704-7
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 600
- Fecha Publicación: 01/05/2019
- Nº Volúmenes: 1
- Idioma: Inglés