The discovery of stem cells has ignited a field of discovery in many human disease areas including diabetes, neurology, and cancer. The tissues from which stem cells have been derived for research have become controversial over the years. Stem cells hold promise in the treatment of debilitating diseases as a new source of therapy. While stem cells may provide therapeutic benefit under certain conditions, stem cells have most recently been implicated in the progression and aggressiveness of certain cancers. Stem cells are characterized by the potential to self-renew, to differentiate, and can sustain tumor growth. Cancer stem cells have been implicated in a variety of tumor types including gliomas, breast, colon, and prostate carcinomas. Hematopoietic stem cell malignancies have been demonstrated in contributing to hematological malignancies suchas leukemia. Mesenchymal stem cells have also been implicated in progression of disease. Will encompass many aspects of stem cells as they pertain to cancer Will introduce the concept of cancer stem cells vs. normal stem cells The first chapters will describe the environmental niche where stem cells reside prior to being recruited to sites of tumorigenesis Separate chapters will distinguish hematopoietic stem cells from mesenchymal stem cells INDICE: From the contents Introduction To Cancer Stem Cells. The Cancer Stem Cell Hypothesis. Tumor Stem Cells and Malignant Cells, One and the Same.- The Stem Cell Niche. Mesenchymal Stem Cells in Tumor Stroma.- Molecular Pathways And Gene Expression. Wnt Signaling in Cancer: from Embryogenesis to Stem Cell Self-Renewal. PTEN in Hematopoietic and Intestinal Stem Cells and Cancer. Transcription Factors in Cancer Stem Cells of the Hematopoietic Lineage. Stem Cell Chromatin Patterns and DNA Hypermethylation. Plasticity Underlying Multipotent Tumor Stem Cells.- Cancer Stem Cells In Solid Tumors. Glioma Stem Cells inthe Context of Oncogenesis. Mouse Mammary Tumor Virus: Stem Cells and MammaryCancer. Tumor Dormancy, Metastasis, and Cancer Stem Cells. Cancer Stem Cells – Gastrointestinal Cancers. Cancer Stem Cells – Hepatocellular Carcinoma. Cancer Stem Cells - Lung Cancer. Cancer Stem Cells – Pancreatic Cancer.-Prostate Stem Cells and Cancer in Animals.
- ISBN: 978-1-60327-932-1
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 330
- Fecha Publicación: 01/05/2009
- Nº Volúmenes: 1
- Idioma: Inglés