Therapy Resistance in Prostate Cancer: Mechanisms and Insights, Volume 20 highlights the main mechanisms that are responsible for therapy resistance in PCa allowing researchers and clinicians to have a synopsis of current options and therapies that can be proposed to overcome resistance. Understanding the mechanisms responsible for chemotherapy resistance helps researchers all over the world delve deeper into the pathways behind this resistance and potentially discover new therapeutic targets for PCa. Prostate cancer (PCa) is among the most diagnosed cancers in men worldwide, as well as one of the most common causes of cancer-related deaths. Despite the advances in treatment, the disease remains associated with poor survival and resistance to cytotoxic and targeted therapies. Tackles the topic of resistance from a broader perspective, including, but not limited to, the role of the extracellular matrix and cancer stem cells in therapy resistanceCreates understanding on how to develop novel therapies that specifically target CSCs to eliminate the regenerating capacity of the tumor and overcome therapy resistanceHelps in identifying novel molecular biomarkers and potential therapeutic targets pertaining to the tumor microenvironment to overcome therapy resistanceProvides a general view of the main pathways involved in PCa progression that will aid in understanding the mechanisms responsible for chemotherapy resistance INDICE: 1. Prostate Gland Anatomy and Hormonal Factors Contributing to Cancer Development 2. Pathophysiology and Molecular Aberrations of Castration Resistant Prostate Cancer 3. Role of Tumor Microenvironment in Prostate Cancer Therapy Resistance 4. Androgen Receptor-Dependent Mechanisms Mediating Therapy Resistance in Prostate Cancer 5. Epigenetic Changes Driving Therapy Resistance in Prostate Cancer 6. Role of Cancer Stem Cells in Prostate Cancer Therapy Resistance 7. Resistance to Taxane Chemotherapies in Prostate Cancer 8. Resistance of Prostate Cancer to Topoisomerase Inhibitors 9. Resistance of Prostate Cancer to Kinase Inhibitors 10. Radioresistance Mechanisms in Prostate Cancer 11. Immunotherapeutic Strategies and Immunotherapy Resistance in Prostate Cancer 12. Overcoming Resistance in Prostate Cancer with Targeted and Small Molecule-Based Therapies 13. Novel Treatment Strategies to Overcome Resistance in Prostate Cancer
- ISBN: 978-0-443-16032-5
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 340
- Fecha Publicación: 24/10/2023
- Nº Volúmenes: 1
- Idioma: Inglés