Sparking signals: kinases as molecular signaltransducers and pharmacological drug targets in inflammation

Protein phosphorylation is an essential post-translational modification that modulates cell–cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance of the protein kinase family is underscored by numerous disease states that arise due todysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics basedon the inhibition of kinase activity. Inhibitors that target protein kinases have proven efficacious in clinical settings and their continued development is the current focus of many drug discovery groups. Internationally well known experts presented their most recent findings on the fast developing kinase field Outstanding interest for basic researchers and pharmaceutical industry. INDICE: Proteomics-bases Strategies in Kinase Drug Discovery.- PKC IsotypeFunctions in T-Lymphocytes.- Molecular and Systems-Biology Approaches to Define Signaling Pathways in Lymphocytes.- Solving the IRAK-4 Enigma. Application of Kinase-Dead Knock-In Mice.- Sensing, Presenting and Regulating PAMPS.- Migration, Cell-Cell Interaction and Adhesion in the Immune System.- The Role of Diacylglycerol Kinases in T Cell Anergy.- Molecular Mechanisms that Control Leukocyte Extravasation Through Endothelial Cell Contacts.- Fragment-Based Drug Discovery Using Rational Design.

• ISBN: 978-3-540-73500-7
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 185
• Fecha Publicación: 01/04/2008
• Nº Volúmenes: 1
• Idioma: Inglés