Inflammation and Immunity in Depression: Basic Science and Clinical Applications

Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder. Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression. Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatryExpands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune systemExplores translational potential of targeting immune dysfunction for clinical interventions INDICE: 1. Introduction 2. Immunological foundations relevant to depression 3. Neuroinflammation in a model of cytokine-induced depression 4. Inflammation in medical-depression comorbidities 5. Neurobiological functions of T cells 6. The role of T-cells in depression 7. Neuroinflammation in post-mortem studies of depression 8. Microglia in depression 9. Animal models of inflammation in depression 10. Epigenetic changes in the immune systems following early life stress 11. The role of the innate immune system in neurodegeneration 12. Inflammation genetics of depression 13. Microglia and neurobiological effects of inflammation in the brain 14. Stress, inflammation and structural brain changes in depression 15. Structural Neuroimaging of inflammation in depression 16. The nerve-gut-inflammation interaction in depression 17. Stress, inflammation and the social brain in depression 18. Epidemiological evidence for the long-term relationship between childhood maltreatment and adult depression 19. Biological embedding of childhood maltreatment in adult depression 20. Inflammation and old age depression 21. Inflammation in clinical depression 22. Role of inflammation in subtypes of depression, recurrent depression and treatment resistant depression 23. The neuroprogression model of depression 24. Inflammation in bipolar depression 25. Neuroprotection and neuroinflammation in depression 26. Sleep disturbance on inflammation and depression risk 27. Clinical anti-inflammatory treatments of depression 28. Efficacy of anti-inflammatory treatments in depression 29. TNF-targeted treatment for depression: does it work, for whom and why? 30. Effects of physical exercise on inflammation in depression 31. Future directions

• ISBN: 978-0-12-811073-7
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 304
• Fecha Publicación: 01/06/2018
• Nº Volúmenes: 1
• Idioma: Inglés