In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while andthen revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. Summarizes the functioning of complex signaling pathways in different tissues and organs of the body in both health and disease Provides insights into the underlying biophysical processes, the associated stable states, and the quantitative methods used for their study Presents the latest research findings as a guide to drug design and tissue engineering INDICE: Matching Energy Supply and Demand.- Introduction.- Glucose/Lipid Homeostasis.- Energy Signal Transduction.- Metabolites and Mitochondria.- Oxidative Balance and Metal-Ion Homeostasis.- Microenvironments.- Inflammation.- The Extracellular Matrix.- Stem Cells and their Niches.- Tissue Repair and WoundHealing.- Metabolic Syndromes.- Obesity.- Diabetes.- Atherosclerosis.- TissueHomeostasis.- Growth and Survival Signaling.- Tumor Growth and Metastasis.- Apoptosis and Senescence.- Amyloidoses and Neurodegeneration.- Protein Folding and Amyloid Formation.- Alzheimer’s Disease.- Parkinson’s Disease, an a-Synucleinopathy.- Huntington’s Disease, a Polyglutamine Disorder.
- ISBN: 978-0-387-98172-7
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 450
- Fecha Publicación: 01/07/2009
- Nº Volúmenes: 1
- Idioma: Inglés