Evolutions Clinical Guidebook: Translating Ancient Genes into Precision Medicine

Evolution's Clinical Guidebook: Translating Ancient Genes into Precision Medicine demonstrates, through numerous well-documented examples, how an understanding of the phylogenetic ancestry of humans allows us to make sense out of the flood of genetic data streaming from modern laboratories, and leads us to new ways to prevent, diagnose, and treat diseases. The biological steps that precede the development of disease are conserved cellular pathways, that evolved at particular moments in ancestral species. If we want to understand the pathways that lead to disease, we need to look at how and why these pathways evolved and the functions they served at particular stages in an organism's development. The book discusses topics such as evolution and human genome; meiosis and other recombinants events; embryology; speciation; phylogeny; rare and common diseases; and the evolution of aging and the diseases thereof. This book is a valuable source for bioinformaticians and several members of biomedical field who needs to have knowledge on evolution, especially on genes level, to fully comprehend and take advantage of all data currently available on biomedical databases, in order to interpret it and pursue new approaches and developments on the bed side. Offers an innovative approach, focusing on how disease-associated pathways evolvedExplains how the fields of phylogeny and embryology have become closely tied to the fields of genetics and bioinformaticsThrough many examples, demonstrates how students and biomedical professionals can apply the knowledge obtained in this book to the theory and practice of Precision Medicine INDICE: 1. Evolution, from a Clinical Perspective 2. Evolution and the Human Genome 3. Meiosis and other Recombination Events 4. Embryology 5. Speciation 6. Diversity and Classification 7. Phylogeny 8. The Evolution of Aging, and the Diseases Thereof 9. Rare diseases Versus Common Diseases 10. Trapped by Evolution

• ISBN: 978-0-12-817126-4
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 350
• Fecha Publicación: 03/06/2019
• Nº Volúmenes: 1
• Idioma: Inglés