NMR of biomolecules: towards mechanistic systems biology

INDICE: PART I INTRODUCTION 1 NMR and its place in Mechanistic Systems Biology (Bertini, McGreevy, Parigi) 2 The structure of biomolecules: fundamentals 2.1 Structural features of proteins (Banci, Cantini) 2.2 Nucleic acids (Schwalbe) 3 What can be learned about the structure and dynamics of biomolecules from NMR (Turano) PART II THE STRATEGIC ROLE OF NMR IN THE STUDY OF THE STRUCTUREAND DYNAMICS OF BIOMOLECULES AND BIOMOLECULAR INTERACTIONS 4 Biomolecules 4.1Proteins (Griesinger, Zwecksetter, Lee) 4.2 DNA (PLAVEC) 4.3 RNA (Stefl, Sklenar) 4.4 Intrinsically disordered proteins (Felli, Pierattelli) 4.5 Paramagnetic molecules (Bertini, Luchinat, Parigi) 5 Biomolecular interactions 5.1 NMR tools and the analysis of protein-protein interactions 5.1.1/2 Triggered stronginteractions/weak interactions (Sattler, Madl) 5.1.3 Metal-mediated interactions (Ciofi) 5.2 Protein-paramagnetic protein interactions (Keizers, Hiruma, Ubbink) 5.3 Protein-RNA interactions (Manoharan, Perez-Canadillas, Ramos) 5.4 Protein-DNA interactions (Boelens, Kovacic) 6 NMR in drug discovery 6.1 General (Pellecchia) 6.2 NMR methods for fragment-based approaches (Sledz, Ciulli) 6.3Interactions of metallodrugs with DNA (Liu, Sadler) 6.4 RNA (Schwalbe, Wohnert) 6.5 19F NMR spectroscopy applied to drug discovery and systems biology (Dalvit) 6.6 NMR of peptides (Beck, Frank, Kessler) 7 Solid-state NMR 7.1 Principles (Emsley, Pintacuda) 7.2 Microcrystalline proteins (Oschkinat) 7.2.1 Microcrystalline paramagnetic molecules (Luchinat) 7.3 Structural studies of amyloids, prions and misfolded proteins by solid-state NMR (Meier, Bockmann) 7.4 Membrane proteins (Renault, Cukkemane, Baldus) 8 Frontiers in NMR spectroscopy 8.1 Dynamic nuclear polarization (Prisner) 8.2 13C direct detection NMR (Felli, Pierattelli) 8.3 Fast methods (Brutscher, Marion, Frydman) 8.4 Metabolomics (Tenori) 8.5 In-cell NMR (Cowburn, Dutta, Shekhtman) 8.6 Membrane proteins (Sobhanifar, Reckel, Lohr, Bernhard, Doetsch) 9 Computational aspects 9.1 Grid computing (Rosato) 9.2 HADDOCK (Melquiond, Karaca, Schmitz, de Vries, Bonvin) 9.3 Structure determination (Guerry, Herrmann) 9.4 Respective localization of the ligand and target (Schwalbe) 9.5 SAXS/SANS-NMR (Petoukhov, Svergun)

• ISBN: 978-3-527-32850-5
• Editorial: Wiley-VCH
• Encuadernacion: Rústica
• Páginas: 696
• Fecha Publicación: 07/03/2012
• Nº Volúmenes: 1
• Idioma: Inglés