Dynemicin A, Uncialamycin and Analogues

Dynemicin A, Uncialamycin and Analogues describes the isolation of dynemicin and uncialamycin, provides a brief overview of their biological activities (and potential development as drugs), and presents the various synthetic routes to prepare these compounds as well as analogues. Dynemicin, uncialamycin, and anthraquinonic derivatives are natural compounds wtih potent antibacterial and anticancer activities due to their unique enediyne moiety. One of the main strengths of this topic is the coverage of a complete field of organic chemistry at the interface with biological science. This ranges from the isolation to the synthesis of natural products (and analogues) possessing enediyne and anthraquinone moieties via their biological activities. Presents two natural ènediynes with similar structures whose total syntheses have been accomplishedExplores structural analogs of preparation for purposes of optimizing the anti-cancer activityDescribes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adoptedFeatures studies of the biological activities and data to bring out the structural elements of these essential compounds INDICE: 1. Introduction; the enediynes : A brief overview of the different kinds of derivatives from this family2. Isolation of Dynemicin and Uncialamycin3. Biological activities4. Total Syntheses5. Perspectives and Conclusion

• ISBN: 978-1-78548-150-5
• Editorial: ISTE Press - Elsevier
• Encuadernacion: Cartoné
• Páginas: 160
• Fecha Publicación: 01/06/2016
• Nº Volúmenes: 1
• Idioma: Inglés