YY1 is Pivotal in the Control of the Pathogenesis and Drug Resistance of Cancer: A Critical Therapeutic Target

YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer: A Critical Therapeutic Target describes, for the first time, the current state of the art of the transcription factor YY1, overexpressed in the majority of cancers and a central factor that regulates all of the major features and characteristics of human cancers. It provides compelling evidence of the novel potential therapeutic intervention by targeting YY1, which would result in the reversal of tumor cell properties and would propose YY1 as a novel prognostic/diagnostic biomarker for human cancers. This book emphasizes the biochemical, molecular, and genetic underlying mechanisms by which YY1 regulates its pro-cancerous activities. In addition, it also describes the role of YY1 in the regulation of tumor cell resistance to conventional chemo and immunotherapies, the important role of inhibiting YY1 in cancer and proposes the development of new therapeutic drugs that inhibit YY1.The book is a valuable source for cancer researchers, oncologists and several members of medical and biomedical field who are interested in understanding further the role of YY1 in cancer. Provides a thorough understanding of the underlying mechanisms by which YY1 regulates cancer cell phenotype and unique characteristicsDiscusses novel mechanisms of YY1 regulation of tumor cell resistance and means to overcome resistanceEncompasses new examples of newly developed non-toxic and selective inhibitors targeting YY1 INDICE: 1. General introduction of YY1 2. Expression of YY1 in various human cancers: Prognostic significance 3. Regulation of YY1 transcription and post-transcription 4. YY1 and proliferation 5. Role of microRNAs targeting YY1 6. YY1 repression of various genes in various cancers 7. YY1 regulation of EMT and metastasis 8. YY1 regulation of the cancer stem cell phenotype 9. YY1 regulation of autophagy 10. YY1 regulation of resistance to chemotherapy 11. YY1 regulation of resistance to immunotherapy 12. YY1 phosphorylation 13. YY1 epigenetic regulation 14. YY1 regulation of the Warburg Effect 15. YY1 inhibitors 16. YY1 versus YY2 17. Future perspectives and conclusions

• ISBN: 978-0-12-821909-6
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 250
• Fecha Publicación: 01/11/2020
• Nº Volúmenes: 1
• Idioma: Inglés