Molecular and Cellular Therapies for Motor Neuron Diseases

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig's Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseasesEdited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevancePresents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy INDICE: 1. Molecular and Extracellular Cues in Motor Neuron Specification and DifferentiationRaymond L. Swetenburg, Steve L. Stice and Lohitash Karumbaiah2. Natural History of ALSMarcus J. Magnussen and Jonathan D. Glass3. Genetics of ALSKevin P. Kenna, John E. Landers and Nicola Ticozzi4. Molecular Mechanisms of Amyotrophic Lateral SclerosisMahlon Collins and Robert Bowser5. An Introduction to the Natural History, Genetic Mapping, and Clinical Spectrum of Spinal Muscular AtrophyAnnie McDonough, Lyndsey Urquia and Nicholas M. Boulis6. Genetics of Spinal Muscular AtrophyArthur H.M. Burghes and Vicki L. McGovern7. Introduction to Gene and Stem Cell TherapyDeirdre O'Connor8. Gene Therapy for ALS 1: Therapeutic TransgenesAnthony Donsante9. Stem Cell Therapy for ALSKevin S. Chen and Eva L. Feldman10. Gene Therapy for Spinal Muscular AtrophyMadeline R. Miller, Erkan Y. Osman and Christian L. Lorson11. Cellular Therapy for Spinal Muscular Atrophy: Pearls and PitfallsIrene Faravelli and Stefania Corti12. Clinical Trials to DateBurton J. Mader and Nicholas M. Boulis

• ISBN: 978-0-12-802257-3
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 350
• Fecha Publicación: 01/01/2017
• Nº Volúmenes: 1
• Idioma: Inglés