Immunological Aspects of Preterm Birth: Phenotypes of Preterm Birth, Immune Mechanisms, and Pathway Forward

Immunological Aspects of Preterm Birth: Phenotypes of Preterm Birth, Immune Mechanisms, and Pathway Forward bridges reproductive immunology of preterm birth to subtypes, phenotypes, and bedside prevention and treatment. The book reviews the role of the different immune mechanisms during pregnancy leading to preterm birth and fetal programming effects that are connected to maternal immune activation. The book also discusses immune cells and their products, cytokines and chemokines, as central for the success of the pregnancy, from the process of implantation to parturition and the effects of the changes on fetal programming. While our knowledge on the role of immune cells and the inflammatory process in preterm birth has grown exponentially in the last 10 years, connecting basic science to clinical science and development of new therapeutics has not progressed as rapidly. This book assists researchers in understanding the basic immunologic mechanisms and inflammatory processes associated with preterm birth and fills an urgent need for the development of therapeutics in this space. Provides a detailed evaluation of preterm birth subtypes and phenotypesEvaluates each immune cell type and its function in maternal peripheral system, placenta, and fetusGives the biological background for understanding the clinical aspects, including treatment venues and effects on fetal programming INDICE: 1. Preterm labor, preterm birth and prematurity: Molecular and clinical phenotypes2. Screening, diagnosis and therapeutic approaches to preterm labor3. Potential use of biomarkers as therapeutic targets of immunotherapy in preterm birth4. Fetal and placental inflammation in preterm birth5. Innate Immunity: the role of macrophages and beyond6. The role of T cells and other adaptive immune mediators in preterm birth7. Spontaneous preterm birth: Immunoperinatology perspective8. Fetal pathophysiological changes in preterm birth9. Vaginal microbiome and preterm birth10. Viral infections and preterm birth11. Environment-immune interactions and epigenetics in preterm birth12. Special considerations: Pregnancy and organ transplantation13. Placenta: Window into neonatal health14. Neonatal outcomes following preterm birth15. Spontaneous preterm birth: Current therapies and opportunities for the future16. Pathway forward

• ISBN: 978-0-443-21564-3
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 262
• Fecha Publicación: 01/01/2025
• Nº Volúmenes: 1
• Idioma: Inglés