The Multitasking Molecular Chaperone HSP60: Structure, Function, and Impact on Health and Disease

The Multitasking Molecular Chaperone HSP60: Structure, Function, and Impact on Health and Disease provides a complete overview of HSP60. It analyzes the molecular structure, localization and functions of HSP60 in normal and pathological cells and tissues in humans. The book then moves on to discuss the role of abnormal HSP60 in disease, considering it across a wide range of skin disorders, heart and blood vessel diseases, respiratory diseases and digestive disorders among others. Genetic chaperonopathies are also covered, and the book moves on to discussion of Hsp60-based therapeutic strategies that can be implemented in the treatment of some diseases.This book is an invaluable reference for researchers and students in molecular biology, biochemistry, biophysics, biomedicine, pharmacology and related life sciences. Discusses therapeutic strategies for diagnosis, patient monitoring, and treatment of disorders in which HSP60 plays a roleConsiders the fundamental biophysics, genetics, and comparative phylogeny of HSP60Explores the mechanisms involving HSP60 abnormalities that lead to disease, including carcinogenesis, inflammation, autoimmunity, and neurodegenerative disorders INDICE: 1. The Chaperone System and its Diseases: Introductory Overview Focusing on Hsp602. Physical and Biochemical Properties of the Molecular Chaperone Hsp603. The Spectrum of Human Hsp60 Genetic Variants and Associated Chaperonopathies4. Hsp60 in Inflammation and Autoimmunity5. Hsp60 and Carcinogenesis6. Hsp60 Involvement in Cartilage Tissue Homeostasis and Pathogenesis7. Hsp60 and Skeletal Muscle Diseases8. Hsp60 and Cardiovascular Diseases9. Hsp60 in Physiology and Pathophysiology of the Respiratory System

• ISBN: 978-0-443-23996-0
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 400
• Fecha Publicación: 14/11/2024
• Nº Volúmenes: 1
• Idioma: Inglés