Neuropathology of Aging and Alzheimers Disease

Neuropathology of Aging and Alzheimer’s disease takes a foundational approach to the topic by offering basic scientific information and the latest advancements in the field. The focus of this reference is on neuropathology, given recent advances in tissue characterization in aging and in Alzheimer’s Disease. Neuropathology has direct relevance to therapeutic constructs and allows for an in-depth understanding of disease pathogenesis. It is a synthesis of the salient issues with respect to pathology, pathogenesis, diagnosis, disease, normal aging, biomarker relevance, and prospects for therapeutic intervention, based on a collective of many decades on the part of the authors confronting the challenges of both science and neuropathological diagnosis. Provides clinical aspects of detection, diagnosis, and treatment, to fully address the disease topicPresents Pathology of atosomal dominant Alzheimer’s disease and Down syndromeIncludes the latest research information on COVID and Alzheimer’s disease INDICE: 1. Historical evolution of Alzheimer’s disease and age-related pathology from Alzheimer forward2. Introduction to the neuroanatomy of AD3. Neurohistologic techniques and methodology4. Plaque pathology5. Neurofibrillary degeneration6. Other Alzheimer disease and age-associated pathology - granulovacuolar degeneration, Hirano bodies, cerebral amyloid angiopathy7. Consensus efforts for dementia brain interpretation at autopsy8. Pathology of autosomal dominant Alzheimer’s disease and Down syndrome9. Aging-related tau - primary age-related tauopathy, aging-related tau astrogliopathy, argyrophilic grain disease10. TDP-43 in aging and Alzheimer’s disease11. Cerebrovascular disease and cognition12. Challenges with clinicopathological correlation13. COVID and Alzheimer’s disease14. Ethical considerations in the neuropathological diagnosis of AD15. Neuropathology and the so-called amyloid cascade16. The diagnostic process in neurodegenerative diseases, including ethical considerations

• ISBN: 978-0-323-99651-8
• Editorial: Elsevier
• Encuadernacion: Rústica
• Páginas: 320
• Fecha Publicación: 01/02/2025
• Nº Volúmenes: 1
• Idioma: Inglés