Ion channel drug discovery is a rapidly evolving field fuelled by recent, butsignificant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium (Feb 2009). This book aims to build on the platform created by this meeting, covering themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels both voltage-gated and non-voltage-gated channels. INDICE: Preface; Chanelling drug discovery; Chanome old and new; High throughput screening; Automated electrophysiology; Structure/crystallization/modeling studies; Toxins - does nature do ion channel drug discovery better than us? Structure and function of Sodium Channels, pharmacophores and binding sites;AMPA modulators - a case history; Inhibition of the epithelial sodium channel(ENaC) as a therapeutic approach to respiratory disease; CFTR channel modulation as a therapeutic approach; TRPs are a pain: a case history on TRPV1 antagonist development; The Retigabine story - the M current to therapeutically useful anticonvulsant; Icrac and Orai - a STIMulating channel; hERG past, present and future? Antibodies as ion channel modulators; Summary and the future; Index
- ISBN: 978-1-84973-186-7
- Editorial: Royal Society of Chemistry
- Encuadernacion: Cartoné
- Páginas: 464
- Fecha Publicación: 31/12/2012
- Nº Volúmenes: 1
- Idioma: Inglés