Preclinical Research in Down syndrome: from bench to bedside, Volume 249, the latest release in the Progress in Brain Research series, highlights new advances in the field. Down syndrome (DS) has been recognized as a clinical entity for about 150 years, but it is only recently that there has been hope for the possibility to understand its pathogenesis and to use this information to devise approaches for the prevention and treatment of its numerous features. This book reviews pioneering work that has defined our understanding of DS. New promising mouse models of DS that open new opportunities to study pathomechanisms and preclinical pharmacological therapies, new genomic perspectives, including genetic and epigenetic mechanisms underlying cognitive deficits, gene expression dysregulation domains, and allelic differences in mouse models. World leading authors also present their work on stem cell and organoids for molecular and cellular research with a number of important potential research applications to better understand DS. In each chapter the authors also discuss the translational validity and implications of pharmacotherapies in preclinical models of DS. Renowned authors review the state-of-the-art in preclinical research Down syndrome and provide their views and perspectives for the future of the fieldChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive and in depth background information and are written in a clear form that is also accessible to the non-specialist INDICE: 1. Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Dow syndrome Eugene Yu 2. The trisomy paradox: gene expression dysregulation domains Stylianos Antonarakis 3. Influence of allelic differences in mouse models of Down syndrome Randall J. Roper 4. Modelling Down syndrome in cells: from stem cells to organoids Dean Nizetic 5. Modelling Down syndrome in animals from the early stage to the new generation of models Yann Herault 6. Mapping behavioral landscapes in Down syndrome animal models María Martínez de Lagrán 7. Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of Chromosome 21 Frances Kendra Wiseman 8. Translational validity and implications of pharmacotherapies in preclinical models of Down syndrome Carmen Martínez Cué 9. Focusing on cellular biomarkers: the endolysosomal pathway in Down syndrome Marie Claude Potier 10. Forecasting the future roadmap for Down syndrome preclinical research William Mobley
- ISBN: 978-0-444-64256-1
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 358
- Fecha Publicación: 01/09/2019
- Nº Volúmenes: 1
- Idioma: Inglés