Successful randomized trials: a handbook for the 21st century

This handbook is a ready reference on the theory and operation of modern large, multicenter randomized clinical trials, which have come to be the basis of evidence-based medicine. Written in a concise, engaging style geared to physicians, the book explains the rationale and theoretical foundations for clinicaltrials, the components of modern clinical trials including their functions and interactions, and practical considerations in the design and implementation of these studies including an introduction to the economics and business aspects. ÍNDICE: CLINICAL TRIAL PRINCIPLES Randomized Clinical Trials Michael Domanski and Sonja McKinlay Designing Clinical Trials Susan F. Assmann Randomization: What It Is and How to Do It Catherine E. Hewitt and David J. Torgerson Setting Sample Size for Randomized Clinical Trials Xin Tian, Sonja M. McKinlay andNancy L. Geller Analytic Approach and Methods Lynn Sleeper Ethical Considerations Lawrence M. Friedman and Eleanor B. Schron LARGE MULTICENTER TRIALS: STRUCTURE AND CONDUCT Study Organization and Governance Abdel Babiker Quality Assurance and Quality Control Sandi Siami Quality Assurance: Prevention of MissingData James Neaton THE FUTURE Surrogate Endpoints Robert Fiorentino RegistriesHesha Duggirala Gazing Into the Crystal Ball: The Future of Randomized Clinical Trials Michael Domanski, Sonja McKinlay, and Marc Pfeffer

• ISBN: 978-0-7817-7945-6
• Editorial: Lippincott Williams and Wilkins
• Encuadernacion: Rústica
• Páginas: 224
• Fecha Publicación: 15/12/2008
• Nº Volúmenes: 1
• Idioma: Inglés