Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress, challenges and future prospects, Comparison of knowledge-based vs. combinatorial peptide library approaches for the identification of protein kinase substrates, and more. Contains timely chapters written by well-renown authorities in their fieldIncludes a number of high-quality illustrations, figures and tables, and targets a very wide audience of specialists, researchers and studentsIntegrates experimental and computational methods for studying the role of protein kinases in different diseases, along with sections on the design of suitable protein kinase inhibitors for use in the treatment of patients INDICE: 1. Transport Proteins and AMPs: Implications in Human Disease Shailza Singh 2. Protein kinase CK2 inhibition as a pharmacological strategy Maria Ruzzene 3. Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy Imtaiyaz Hassan 4. Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation Shaoyong Lu 5. Pseudokinases in drug discovery and development: progress, challenges and future prospects G Rajanikant 6. Comparison of knowledge-based vs combinatorial peptide library approaches for the identification of protein kinase substrates Amaury Fernández-Montalván 7. Assessment of sub-kinomes using peptide arrays: A novel platform connecting protein kinase activity and systems pharmacology approaches Robert Mccullumsmith 8. Chemogenomics and bioinformatics approaches for prioritizing kinases as drug targets for neglected tropical diseases Carolina Horta Andrade 9. Targeting malaria protein kinases Fabio Costa 10. Yeast-based high-throughput screen for discovery of kinase inhibitors as antiparasitic drug candidates Elizabeth Bilsland 11. Predicting nucleophilic hotspots in protein kinases Jana Shen 12. Structural studies of full-length kinase receptors: Opportunities for drug design Ho Leung Ng
- ISBN: 978-0-323-85313-2
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 350
- Fecha Publicación: 01/03/2021
- Nº Volúmenes: 1
- Idioma: Inglés