Protein Misfolding, Volume 118, covers the wide spectrum of diseases and disorders that are attributed to protein misfolding, including degenerative and neurodegenerative, cardiovascular, renal, glaucoma, cancer, cystic fibrosis, Gaucher's disease, and many others. Specific chapters cover Mass spectrometric approaches for profiling protein folding and stability, Biomembranes, a key player in protein misfolding, how Genetic and environmental factors interact to disrupt proteostasis and trigger protein misfolding diseases, Formation of oligomers and large amorphous aggregates by intrinsically disordered proteins, Protein misfolding in ER stress with applications to cardiovascular and renal disease, and much more. Integrates methods for studying protein misfolding, factors that trigger this process and its role in a wide spectrum of diseases and disordersContains timely chapters written by well-renowned authorities in their fieldProvides data that is well supported by a number of high quality illustrations, figures and tables, and targets a very wide audience of specialists, researchers and students INDICE: 1. Mass spectrometric approaches for profiling protein folding and stability Joseph Genereux 2. Biomembranes, a key player in protein misfolding Kung Huang 3. Genetic and environmental factors interact to disrupt proteostasis and trigger protein misfolding diseases Elise Alexandra Kikis 4. Formation of oligomers and large amorphous aggregates by intrinsically disordered proteins John Adrian Carver 5. Protein misfolding in ER stress with applications to cardiovascular and renal disease Jeffrey G. Dickout 6. Misfolding of vasopressin receptors Bernard Mouillac 7. LOXL1 folding in Exfoliation Glaucoma Audrey Bernstein 8. Misfolding, aggregation and liquid-liquid phase transitions in proteins related to cancer and neurodegenerative diseases Jerson L. Silva 9. Cytotoxic species in amyloid-associated diseases: Oligomers or mature fibrils Rizwan Hasan Khan 10. Challenges in designing small molecule inhibitors of ß-amyloid and Tau oligomerization Donald F. Weaver 11. Theoretical and computational advances in protein misfolding Parbati Biswas 12. Combining molecular dynamics simulations and experimental analyses in protein misfolding Holger Wille 13. Influence of the reducing environment in the misfolding of wine proteins Paolo Ruzza
- ISBN: 978-0-12-817750-1
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 264
- Fecha Publicación: 17/01/2020
- Nº Volúmenes: 1
- Idioma: Inglés