Chemical and Biochemical Approaches for the Study of Anesthetic Function Part B

The mechanisms by which a range of small molecules causes anesthesia remains as unclear as consciousness itself. It is clear, however, that this involves a complex series of interactions spanning the molecular to the organ. Experimental and theoretical approaches towards understanding these mechanisms have therefore had to match the resolution level and have accordingly been enormously varied. This volume is the first attempt to assemble these approaches into a coherent description of the campaign towards understanding anesthesia This provides one-stop shopping for all the means of addressing this complex questionAnesthesia is enormously important as almost everybody receives it at some point INDICE: Computational approaches 1. Physical accuracy leads to biological relevance: Best practices for simulating ligand-gated ion channels interacting with general anesthetics 2. Computational approaches for studying voltage-gated ion channels modulation by general anesthetics 3. Anesthetic parameterization 4. Pharmacophore QSAR, QM, ONIOM 5. Kinetic modeling of electrophysiology data Genetics and model organisms 6. General genetic strategies 7. Worms 8. Flies 9. Tadpoles 10. Zebrafish 11. Mice Photolabeling 12. Mass spect ID of adducts 13. Photolabeling protection/competition Xenon 14. Xenon-protein interactions 15. Xenon gas delivery/recovery procedures 16. Hyperpolarized Xe-129 MRI 17. CT imaging Electrophysiology 18. Native system electrophysiology (slices, cells, in vivo) 19. Voltage-gated ion channels (Kv, Nav) 20. Ligand-gated ion channels 21. Other channels (HCN/K2P/TRP) Structural Approaches 22. Soluble proteins 23. Membrane proteins 24. NMR 25. Time-Resolved Neutron Interferometry and the Mechanism of Electromechanical Coupling in Voltage-Gated Ion Channels Evolving Biophysical Technologies 26. Fluorescent Anesthetics 27. Investigation of anesthetic-protein interactions by a thermodynamic approach 28. Tissue/organism EPR 29. Lipids, Membranes and Pressure reversal In vivo technologies; established and evolving 30. Optoanesthesia 31. Optogenetics, Chemogenetics 32. Genetic reporters of neruonal activity: c-fos, genetically encoded calcium indicators 33. Genomics and Proteomic Techniques 34. Neurochemistry of Anesthetic States 35. Electroencephalography 36. PET 37. Drug discovery and development 38. The use of glutamatergic anesthetics (ketamine, nitrous oxide and xenon) in depression 39. Brain Imaging Using Hyperpolarized 129Xe MRI

• ISBN: 978-0-12-814574-6
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 412
• Fecha Publicación: 01/05/2018
• Nº Volúmenes: 1
• Idioma: Inglés