In the lung, more recent data have been accumulated on lung stem cell biology/function and the potential applications of stem cells in pulmonary diseases that are facilitated by the recent development of a broad range of cutting edge in vitro and in vivo research tools and approaches, including mouse and human organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases. Stem Cell Innovation in Health and Disease: Volume 2: The Lung, contains two major sections describing cutting edge research for understanding stem cell functions in the lung and respiratory system, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model lung diseases, through the cutting-edge research aiming to bring stem cells from bench to bedside, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of lung diseases/disorders. This book, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the lung in the real world. Provides intensive scientific background and most recent information on cutting edge research to understand respiratory stem cell functions and develop methods to bring stem cells from bench to bedside for different lung diseasesAnalyzes the current state, opportunities, and challenges of innovative technologies and stem cells from bench to bed, including organoids and iPSC-derived alveolar epithelia cell therapy in the lungContains two major sections describing cutting-edge research for understanding stem cell functions and for developing methods specific to the lung INDICE: Chapter 1: Cutting-edge tools and approaches for stem cell research and application in pulmonary diseases Chapter 2: Organoid-based modality of lung development, cellular activities, and functions and lung stem cell activities/functions Chapter 3: Lung organoid culture system in pulmonary pathology and drug screening: an innovative testbed for basic and translational approaches Chapter 4: Stem cell-driven tissue engineering in lung engineering, regeneration and diseases Chapter 5: Applications of innovative gene editing technologies in respiratory diseases Chapter 6: iPSCs in the modeling and therapy of lung diseases and airway production Chapter 7: The gold standard embryonic stem cells in lung repair, regeneration, and diseases Chapter 8: Hematopoietic stem cell roles in the treatment of respiratory diseases Chapter 9: Preclinical and clinical applications of mesenchymal stem cell-based therapy in pulmonary diseases Chapter 10: Endothelial Progenitor Cells in Pulmonary Diseases, Repair and Regeneration Chapter 11: General Discussion, Conclusion Remark and Future Direction
- ISBN: 978-0-12-821206-6
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 200
- Fecha Publicación: 01/06/2021
- Nº Volúmenes: 1
- Idioma: Inglés