Physiologically-Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment

Physiologically-Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment aims to take the reader from foundational principles to more advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling will cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, Physiologically-Based Pharmacokinetic (PBPK) Modeling is a foundational resource that provides the practical coverage of PBPK modeling for graduate students, academics, and researchers in toxicology, public health, or environmental sciences who may use these techniques in their research; experienced toxicologists interested in improving their understanding of in silico methods; computational toxicologists interested in refreshing their training in the foundational methods of PBPK modeling; and regulators and policymakers who may be interested in employing PBPK for regulatory purposes. Provides end-of-chapter exercises to learn hands-on computational tools used in toxicologySupplies computer code along with explanations and provides examples of applied models used in regulatory toxicology and researchAuthored by expert editors and contributors who are among the best PBPK modelers in the world INDICE: 1. A history and recent efforts of selected PBPK modeling topics 2. Introduction to Classical Pharmacokinetics 3. Fundamentals of PBPK Modeling 4. PBPK Modeling Software 5. PBPK model: Routes of Chemical Exposures Across Species, Mechanisms of Chemical Absorption 6. PBPK model: Distribution Processes 7. PBPK Model: Metabolism 8. PBPK model: Excretion Via Urine, Feces, And Breath 9. Population PBPK Analysis Methods 10. PBPK Model Calibration, Evaluation, and Performance Assessment 11. Local and Global Sensitivity, Uncertainty And Variability Analyses 12. PBPK modeling In Risk Assessment 13. Tox21, Emerging Methods. High-Throughput Data, And IVIVE

• ISBN: 978-0-12-818596-4
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 300
• Fecha Publicación: 01/08/2020
• Nº Volúmenes: 1
• Idioma: Inglés