RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo. Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery. The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics. Brings together information on the current state of the RGS protein fieldContains comprehensive descriptions of the known pathophysiological and physiological functions of RGS proteins, the first such undertakingGives particular emphasis to the ways these discoveries inform healthcare and drug discovery INDICE: RGS10 in neuroinflammation and neuroprotectionMalú G. Tansey and Jae Kyung Lee RGS molecules and vascular pathologiesRuth GanssRGS protein regulation of phototransductionChing-Kang Jason ChenRGS2: a versatile regulator of vascular function and signalingKendall J. Blumer and Patrick Osei-Owusu RGSs in BoneYi-Ping LiRGS14 in synaptic plasticity, learning and memoryJohn R. HeplerRGS protein suppression of Go mediated seizuresRichard NeubigTwo for the price of one: G protein-dependent and -independent functions of RGS6 in vivoRory A. Fisher
- ISBN: 978-0-12-802938-1
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 300
- Fecha Publicación: 01/07/2015
- Nº Volúmenes: 1
- Idioma: Inglés