A Paradigm Shift to Prevent and Treat Alzheimers Disease: From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols

A Paradigm Shift to Prevent and Treat Alzheimer's Disease: From Monotargeted Pharmaceuticals to Multitargeted Polyphenols is the first book of its kind to aggregate previously fragmented research on the combination treatment of Alzheimer's disease with non-toxic agents of pleiotropic action. The first part of this book introduces the pleiotropic pharmacological profiles of the featured plant polyphenols and the overarching analytical framework favoring a multi-targeting model of chronic disease prevention and treatment. The second part then applies these pharmacological profiles and the analytical framework to the pathogenic hallmarks of Alzheimer's disease. The third and final part of this book presents the broader evidentiary basis supporting the wider use of plant polyphenols to prevent and treat Alzheimer's disease. With the goal of advancing research, the authors also suggest how to improve drug development and the design and implementation of clinical trials in this area. This is a unique and valuable resource for pharmacologists, neurologists, clinicians and researchers, focusing on the potential preventative and therapeutic effects of pleiotropic targeting of polyphenols on Alzheimer's disease. Presents carefully compiled evidence supporting the need to shift from pharmaceutical-based mono-targeting to plant polyphenol-based pleiotropic targeting for the prevention and treatment of Alzheimer's diseaseIncludes valuable tables that aggregate pleiotropic pharmacological effects of the plant polyphenols on Alzheimer's disease-related pathogenic hallmarksHighlights regulatory aspects and discusses the challenges and potential solutions with respect to bioavailability of certain plant polyphenols INDICE: 1. The Pleiotropic Pharmacology of Plant Polyphenols 2. Target Theory vs. Pleiotropic Theory 3. Primary Prevention of AD 4. Secondary Prevention of AD 5. Treatment Mechanisms in Mild to Moderate AD 6. Strict Scrutiny vs. Rational-Basis Scrutiny

• ISBN: 978-0-12-812259-4
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 256
• Fecha Publicación: 01/08/2017
• Nº Volúmenes: 1
• Idioma: Inglés