INDICE: List of Contributors. Preface. 1 Diagnosis and revision of the classification systems (Assen Jablensky). Introduction. Origin and evolution of the concept of schizophrenia. Kraepelin's 'clinical forms'. Bleuler's 'group of schizophrenias'. Leonhard's 'endogenous psychoses'. Classification of psychoses in French psychiatry. Other post-Kraepelinian and post-Bleulerian subtypes and dichotomies. The schizophrenia spectrum concept. Statistically derived clusters and symptom dimensions. Schizophrenia in ICD-10 and DSM-IV. Origins of the two classifications. Both DSM-IV and ICD-10 are descendants of the Kraepelinian nosology. Criteria for assessing the diagnostic classification of schizophrenia. Positive impact and unintended adverse effects. Clinical relevance and cognitive ease of use. Utility in research. Reliability. Concepts of validity.Predictive validity: course and outcome. Criterion validity: genetics. Aspects of culture. Reducing stigma. Revision of the classifications: prospects for schizophrenia. One classification or many? Critical issues in the revision process. Disease or a broad syndrome? 'Deconstructing' schizophrenia: categories or dimensions? Endophenotypes. The concept of utility. Conclusion. References.2 Pathophysiology of schizophrenia (Peter Falkai, Andrea Schmitt and Tyrone D. Cannon). Introduction. Major findings and related pathophysiological hypotheses. Symptom domains and neurotransmitter hypotheses. From domains to disturbed neuronal networks. From networks to the cellular level. Hypothesis of disturbed synaptogenesis and neurogenesis. Effects of antipsychotics. Summary and conclusions. References. 3 Neurocognition, social cognition and functional outcome in schizophrenia (William P. Horan, Philippe-Olivier Harvey, Robert S. Kernand Michael F. Green). Introduction. Neurocognition in schizophrenia. Domains, measurement and magnitude of impairment. Neurocognition as a core deficit ofschizophrenia. Associations with functional outcome. The NIMH-MATRICS initiative and current research directions. Social cognition. Domains, measurement and magnitude of impairment. Social cognition as a core feature of schizophrenia. Association with functional outcome. Current research directions. Relationships among neurocognition, social cognition and functional outcome. Distinctiveness of neurocognition and social cognition. Social cognition as a mediator. Future directions. References. 4 The genetics of schizophrenia (James T.R. Walters, Michael O'Donovan, Michael J. Owen and Wolfgang Gaebel). Introduction. Genetic epidemiology of schizophrenia. Family, twin and adoption studies of schizophrenia. Genetic epidemiology informing diagnosis? Molecular genetics of schizophrenia. Linkage. Positional candidate studies. Functional candidate studies. Chromosomal abnormalities. Genome wide association studie
- ISBN: 978-0-470-71054-8
- Editorial: John Wiley & Sons
- Encuadernacion: Cartoné
- Páginas: 272
- Fecha Publicación: 01/04/2011
- Nº Volúmenes: 1
- Idioma: Inglés