This volume of Current Topics in Developmental Biology will focus on the role of retinoids during development and disease. Topics covered include the role of retinoic acid and its nuclear receptors in control of several developmental processes including germ cell differentiation/meiosis, somitogenesis, limb formation, hindbrain and spinal cord development, heart formation, eye and craniofacial development, and pancreas formation. Also covered is the role of various retinoids in adult processes including diseases of the visual cycle, obesity, and metabolism. Learn about the role of retinoids from the germ cell to the adult organismDiscover the normal functions of retinoic acid during embryonic developmentAcquire knowledge on how retinoids continue to function in the adult INDICE: PrefaceGregg Duester and Norbert Ghyselinck1. Retinoids, Retinol-Binding Protein 2 (RBP2), Retinol-Binding Protein 4 (RBP4): Obesity and Metabolic DiseaseWilliam S. Blaner2. Early Retinoic Acid Signaling Organizes the Body Axis and Defines Domains for the Forelimb and EyeGregg Duester3. Rethinking Retinoic Acid Self-Regulation: A Signaling Robustness Network ApproachAbraham Fainsod and Rajanikanth Vadigepalli4. Meiotic initiation in the fetal ovary without retinoic acid receptors: an unforeseen twistNorbert Ghyselinck5. Action of retinoic acid on progenitor cells in the testisMichael David Griswold6. Role of Cellular retinoic acid binding proteins (CRABPs) in regulating retinoic acid metabolism and signalingNina Isoherranen7. Retinoic acid homeostasis and diseaseMaureen A. Kane8. Redefining the roles of endogenously produced retinoic acid in heart development and regeneration: lessons from genetic modelsAlexander R. Moise9. The Multifaceted Roles of Retinoids in Vision, Eye Development, and Retinal Degenerative DiseasesKrzysztof Palczewski10. Essential roles for retinoid signaling in craniofacial developmentLisa L. Sandell11. Retinoic acid signaling in pancreas development, islet function, and pancreatic diseasesLori Sussel and David Lorberbaum12. Vitamin A supply in the eye and establishment of the visual cycleJohannes von Lintig
- ISBN: 978-0-323-91700-1
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 362
- Fecha Publicación: 01/02/2025
- Nº Volúmenes: 1
- Idioma: Inglés