The book is focused on the basic mechanisms underlying neurological disorders, presenting clinical information where needed to place into perspective the discussion of mechanisms. The book is aimed at nonclinician neuroscientists, who may possess the conceptual and technical expertise required for productive investigations in translational research but lack frequent contact with scientifically oriented clinicians who can inform them about current concepts and recent developments. The book is divided into two parts, covering topics relevant to the central nervous system (Part A) and the peripheral nervous system (Part B). Within these divisions the topics include many of the major categories of disease process with individual chapters describing the mechanisms underlying specific disorders. Sid Gilman, M.D., Professor, William J. Herdman Distinguished University Professor of Neurology, Department of Neurology, University of Michigan. INDICE: Part A. CENTRAL NERVOUS SYSTEM.- Section I. Metabolic Diseases.- 1. Lysosomal Disorders of the Nervous System.- 2. Neurobiology of Peroxisomal Disorders.- 3. Creatine Deficiency Syndromes.- 4. Leukodystrophies.- Section II. Neurodegenerative Disorders.- 5. Parkinson’s Disease.- 6. Alzheimer’s Disease (update and expand).- 7. Multiple System Atrophy.- 8. Olivopontocerebellar Atrophy (OPCA).- 9. Neurobiology of Progressive Supranuclear Palsy.- 10. Traumatic Brain Injury, Apoptosis, Necrosis – Alan Faden?.- Section III. Genetic Diseases.- 11. Protein Aggregation Disorders.- 12. RNA-Based Disorders of Muscle and Brain.- 13. Ion Channel Disorders.- 14. Spinocerebellar Ataxia Type 1.- 15. Mitochondrial Genetic Diseases (alsarole in apoptosis).- 16. Other organelles – protein misfolding.- 17. Epigenetics.- Section IV. Neuroimmunological Disorders.- 18. Paraneoplastic Neurological Disorders.- 19. Systemic Lupus Erythematosus: Descriptive Past and Mechanistic Future.- 20.Progressive Multifocal Leukoencephalopathy.- 21. Immunopathogenesis of Multiple Sclerosis.- 22. Immune-Mediated Neuropathies.- 23. Hashimoto Encephalopathy.- Section V. Cerebrovascular Diseases.- 24. Vascular Cognitive Impairment.- 25. Cardioembolism.- 26. Clinical and Neurobiological Aspects of Stroke Recovery.- 27. NonatheroscleroticCerebral Vasculopathies.- 28. Subarchnoid Hemorrhage.- 29. Cerebral Ischemia:Molecular Mechanisms and Protective Therapies.- 30. Intracerebral Hemorrhage and Intraventricular Hemorrhage-Induced Brain Injury.- Section VI. Paroxysmal Disorders.- 31.Idiopathic Generalized Epilepsy.- 32. Paroxysmal Dyskinesia.- 33. Myoclonus.- 34. Channelopathies of the Nervous System.- 35. Migraine as a Cerebral Ionopathy with Abnormal Central Sensory Processing.- 36. Temporal LobeEpilepsy.- Section VII. Neoplastic Diseases.- 37. Central Nervous System Metastases.- 38. Meningioma.- 39. Primary Central Nervous System Lymphoma.- 40. Neurofibromatosis.- 41. Medulloblastoma and Primitive Neuroectodermal Tumors.- 42. Glioma.- Section VIII. Infectious Diseases.- 43. Bacterial and Fungal Infections of the Nervous System.- 44. Parasitic Infections.- 45. Prion Diseases.- 46. Central Nervous System Viral Infections: Clinical Aspects and Pathogenic Mechanisms.- 47. HIV Dementia (expand?).- Section IX. Motor Neuron Diseases.- 48. Spinal Muscular Atrophy.- 49. Amyotrophic Lateral Sclerosis-Like Syndromes Associated with Malignancy.- 50. Amyotrophic Lateral Sclerosis: Idiopathic andInherited.- 51. Hereditary Spastic Paraplegia and Primary Lateral Sclerosis.-52. Poliomyelitis.- 53. Spinobulbar Muscular Atrophy.- Section X. Malformations and Developmental Disorders.- 54. Neurobiology of Genetic Mental Retardation.- 55. Cerebral Palsy.- 56. Autism.- 57. Neurobiology of Dyslexia.- 58. Neonatal Brain Injuries.- 59. Spina Bifida.- 60. Circuits to Synapses: The Pathophysiology of Tourette Syndrome.- 61. Attention-Deficit Hyperactivity Disorder.- 62. Congenital Hydrocephalus.- 63. Fragile X (expand?).- Section XI. Neurologic Manifestations of Medical Diseases.- 64. Neurological Manifestations of Hematological Disease.- 65. Neurological Manifestations of Renal Disease.- 66. Diabetes and Endocrine Disorders.- 67. Mechanisms and Consequences of Central Nervous System Hypoxia.- 68. Neurological Manifestations of Gastrointestinal and Hepatic Diseases.- 69. Neurosarcoidosis.- 70. Neurological Manifestations of Heart Disease.- Section XII. Sleep Disorders.- 71. REM Sleep Behavior Disorder.- 72. Neurobiology of Narcolepsy and Hypersomnia.- 73. Restless Legs Syndrome and Periodic Limb Movements in Sleep.- 74. Neurobiology of Insomnia.- Section XIII. Substance Abuse and Basic Toxicology.- 75. Assessment of NeurobiologicalDiseases with Magnetic Resonance Spectroscopy.- 76. Magnetic Resonance Imaging.- 77. Neurovascular Computed Tomography.- 78. PET Imaging in Parkinson’s Disease and Other Neurodegenerative Disorders.- 79. Single-Photon Emission Computed Tomography.- 80. Functional Magnetic Resonance Imaging.- PART B. PERIPHERALNERVOUS SYSTEM.- Section XV. Peripheral Neuropathies.- 81. Impaired Glucose Regulation.- 82. Acquired Inflammatory Demyelinating and Axonal Neuropathies.- 83.Toxic and Drug-Induced Neuropathies.- 84. Inherited Peripheral Neuropathies.- 85. Neurological Manifestations of Vasculitis.- 86. Neuropathies Associatedwith Infections.- Section XVI. Myopathies and Neuromuscular Junction Disorders.- 87. Muscular Dystrophies.- 88. Myasthenia Gravis and Myasthenic Syndromes.- 89. Metabolic Myopathies.- 90. Immunobiology of Autoimmune Inflammatory Myopathies.- Section XVII. Autonomic Disorders.- 91. Central Autonomic Network.- 92. Autonomic Neuropathies.- 93. Thermoregulation and Its Disorders.- 94. Control of Blood Pressure—Normal and Abnormal.- Section XVIII. Pain.- 95. Neoplasm-Induced Pain.- 96. Pain Associated with the Autonomic Nervous System.- 97. Postherpetic Neuralgia.- 98. Central Post-Stroke Pain.- 99. Hyperalgesia.- 100. Allodynia.- 101. Neuropathic Pain.- 102.Insensitivity to Pain
- ISBN: 978-1-4614-0389-0
- Editorial: Springer
- Encuadernacion: Rústica
- Fecha Publicación: 02/05/2013
- Nº Volúmenes: 1
- Idioma: Inglés