Breast Cancer is the most common tumor in women and the second leading cause of cancer deaths worldwide. Due to breakthroughs in gene profiling, the knowledge of the pathophysiology of the mammary gland had greatly increased over thelast decade. In Breast Cancer in the Post Genomic Era, Antonio Giordano, Nicola Normanno, and a panel of international authorities in their field provide acomprehensive approach to the biology, diagnosis, prevention, and treatment of human breast carcinoma. The book provides a comprehensive approach to breastcancer, describing the use of gene profiling techniques to distinguish specific features of individual carcinomas, as well as emerging novel therapeutic approaches to treatment. Additional chapters cover the use of transgenic mice tomodel human breast cancer and the role of the EGF-CFC family in mammary glanddevelopment and neoplasia. Breast Cancer in the Post Genomic-Era succeeds in looking at breast cancer pathogenesis, diagnosis, and treatment under a more comprehensive light, and is a valuable resource for any Radiation or Surgical Oncologist, Cancer Biologist or Pathologist. Highlights the most recent findings in the field of tumor biology, as well as the development of novel diagnostic procedures and therapeutic approaches in breast cancer Provides a comprehensive approach to the biology, diagnosis, prevention, and treatment of human breast carcinoma INDICE: The genomic basis of breast development and differentiation.- Mammary Glands, Stem Cells and Breast Cancer.- The genetics of breast cancer: application in clinical practice.- Alterations in cell cycle regulatory genes in breast cancer.- Neuregulins in the nucleus.- Role of the EGF-CFC family in mammary gland development and neoplasia.- Modeling human breast cancer: the use oftransgenic mice.- Gene expression profiling in breast cancer: clinical applications.- TGF-B signaling: a novel target for treatment of breast cancer?- DNA methylation in breast cancer.- Signal transduction inhibitors in the treatmentof breast cancer.- Integration of target based agents in current protocols ofbreast cancer therapy.
- ISBN: 978-1-60761-466-1
- Editorial: Humana
- Encuadernacion: Rústica
- Páginas: 230
- Fecha Publicación: 01/07/2010
- Nº Volúmenes: 1
- Idioma: Inglés