Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspectivePromotes crosstalk between basic sciences and their applications in medicineProvides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principlesIntegrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes INDICE: 1. Dynamics and function of DNA methylation during development2. Histone modifications in pluripotency and differentiation3. ATP-dependent Chromatin remodelling: from early development to cancer4. Regulation of cellular identity by Polycomb and Trithorax proteins5. Crosstalk between chromatin marks at regulatory elements6. Chromatin modifications and transcriptional noise in cell fate decision7. Chromatin dynamics during the cell cycle8. Chromatin dynamics and DNA repair9. Epigenetic regulation of replication and replication timing10. Interplay between chromatin and splicing11. Nuclear lipids and the regulation of chromatin12. Nuclear architecture and epigenetic memories: Heterochromatin formation in development, senescence and cancer13. Noncoding RNAs and the third dimension of the epigenome14. Epigenetic control of the nucleolus 15. X chromosome inactivation in 3D16. Telomere maintenance in the dynamic nuclear architecture17. Interaction between cellular metabolic states and chromatin dynamics18. Circadian plasticity of the epigenome 19. The epigenome at the gene-environment interface in complex disease
- ISBN: 978-0-12-803395-1
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 400
- Fecha Publicación: 01/06/2016
- Nº Volúmenes: 1
- Idioma: Inglés