Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series provides timely and critical reviews of important topics in medicinal chemistry with an emphasis on emerging topics in the biological sciences that are expected to provide the basis for entirely new future therapies. Unique for its treatment of platform technologies for medicinal chemistry and target validationProvides a single, rich volume that summaries a broad spectrum of expertise relevant to the fieldPresents state-of-the-art summaries of platform technologies INDICE: 1. DELT Barry Morgan 2. Oligos: ASO, siRNA Dave Rozema 3. CRISPR Sylvie Guichard 4. Mircro-fluidic chemistry Urge Laszlo 5. High throughput screening Jonathan Connick 6. Kinase-centric computational drug development Andrea Volkamer and Albert J. Kooistra 7. Virtual Screening Mark Ashwell 8. Phenotypic screening Alleyn Plowright 9. PROTACS Tim Rassmussen 10. Chemical Biology Paola Castaldi and Piero Ricchiuto 11. Fragment-based lead generation Ben Davis 12. Antibody-Drug Conjugates Changshou Gao 13. Antibody-recruiting small molecules Andrew Zhang, Patrick McEnaney and Christopher Parker 14. Deuteriation Dario Doller 15. Peptides Claudio D. Schteingart
- ISBN: 978-0-12-813069-8
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 310
- Fecha Publicación: 01/12/2017
- Nº Volúmenes: 1
- Idioma: Inglés