Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation

The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential for those involved in drug safety evaluation, including pathologists, toxicologists and pharmacologists working in corporate, government, academic and research settings. NEW TO THE FOURTH EDITION: *This edition is in full color and features nearly 200 high-quality images *Provides extended commentary on the relevance of pathological findings and features a fully updated bibliography containing sources for further reading *Includes new content coverage on the commonly used transgenic animal models that are used in safety assessment, specific tumor types induced by drugs in rodents, and new drug-induced pathologies and lesions. INDICE: Chapter 1: IntroductionChapter 2: Integumentary System- Skin and subcutaneous tissueChapter 3: Mammary GlandChapter 4: Haemopoietic and Lymphatic Systems- Blood/bone marrow- Lymphoid system- Lymph nodes- Spleen- Thymus- Lymphoreticular neoplasmsChapter 5: Musculoskeletal System- Bone- Joints- Skeletal muscle Chapter 6: Respiratory Tract- Nose, nasal sinuses, nasopharynx and pharynx- Larynx and trachea- Bronchi and lungsChapter 7: Cardiovascular System- Heart and pericardium- Systemic blood vessels- Pulmonary blood vesselsChapter 8: Gastrointestinal tract- Forestomach- Stomach (glandular)- Small intestine- Large intestineChapter 9: Liver and Pancreas- Liver- Bile ducts, biliary system - PancreasChapter 10: Urinary System- Kidney- Urinary bladderChapter 11: Male Genital Tract- Prostate gland- Epididymis- TestisChapter 12: Female Genital Tract- Vagina- Cervix- Uterus- OvaryChapter 13: Endocrine System- Pituitary gland- Adrenal gland- Thyroid gland- Parathyroid glandChapter 14: Nervous System and Special Sense Organs- Brain- Spinal cord, spinal nerve roots, peripheral nerves- Eye- EarSubject index

• ISBN: 978-0-444-53856-7
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 892
• Fecha Publicación: 23/11/2011
• Nº Volúmenes: 1
• Idioma: Inglés