Introductory Review on Sirtuin in Biology and Disease

Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Thus, it is rather difficult to grasp the broad impact of sirtuins in biology, and a book like this will be very useful as it will integrate diverse areas of knowledge. Introductory Review on Sirtuins in Biology and Disease integrates this knowledge and provides a current view of the sirtuin field. This comprehensive reference provides key insights for scientists as well as advanced students who need basic knowledge of sirtuins and current research status in this field. Pharmaceutical companies will use this book for their development of novel targets by using sirtuins for metabolic diseases, cancer, and neurodegenerative diseases. Covers both general and more specific aspects of sirtuin proteins and their role in biology, aging and diseaseTop quality collection of leading experts on a rather wide range of sirtuin-related topics INDICE: 1. Early Sirtuin Research 1991-2000 2. Regulation of sirtuins by systemic NAD+ biosynthesis 3. NAD modulation - biology and therapy 4. The enzymatic activity of sirtuins 5. Molecular mechanisms of Sirtuin activation and inhibition 6. Pharmacological approaches for modulating sirtuins 7. Mitochondrial Sirtuins 8. Biological Roles and Activities for Mitochondrial Sirtuins 9. The multitasking roles of the mammalian deacetylase SIRT6 10. Chromatin and nuclear signaling: SIRT7 function in the nucleolus and beyond 11. Sirtiuns and Carcinogenesis 12. Roles for sirtuins in cardiovascular biology 13. Sirtuins in Brain Biology and Disease

• ISBN: 978-0-12-813499-3
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 130
• Fecha Publicación: 01/05/2018
• Nº Volúmenes: 1
• Idioma: Inglés