Preclinical drug discovery v. 1 Biochemical methods in high throughput screening

This book is one of a three-volume set that provides theoretical, practical and troubleshooting guidelines on all aspects of the pre-clinical Drug Discovery process. There is particular focus on the design, development and role of screening assays in Drug Discovery, including new developments and future trends, the main assay types utilized in screening campaigns, and the methods utilized in enabling the progression of "Hits" to "Leads" and "Candidates" The bookswill also fill current gaps in the literature such as primary, stem cell and other novel assay methods. Other relatively new research areas included are siRNA, high content screening, protein-protein interactions, pathway assays, nonmicro-titre plate based assays, label free assays, IT tools, approaches to identify biopharmaceuticals, emerging models and future trends in Drug Discovery. INDICE: Volume 1: Biochemical Methods in High Throughput Screening: Absorbance; Fluorescence intensity; Fluorescence polarisation; FRET, TR-FRET/HTRF; AlphaScreen; Fluorescence lifetime; Scintillation Proximity Assay; Chip based assays; Label free assays; Calorimetry; ELISA;

• ISBN: 978-1-84973-139-3
• Editorial: Royal Society of Chemistry
• Encuadernacion: Cartoné
• Páginas: 256
• Fecha Publicación: 30/09/2012
• Nº Volúmenes: 1
• Idioma: Inglés