Co-existence and co-release of classical neurotransmitters: ex uno plures

Dale's Principle postulated that a neuron functions as a metabolic unit, whereby a process occurring in the cell can influence all of the compartments of that given neuron. This was unfortunately transformed in the literature to a principle stating that “a single cell releases only one neurotransmitter”. Untilrecently, this has influenced many neuroscientists to consider with skepticism the idea that classical neurotransmitters could be co-released from neurons.It is now clear that the “one neuron, one neurotransmitter” postulate is the exception rather than the rule. The aim of this book is to gather the available evidence, provided by the authors that have discovered and studied the co-existence or co-release of several pairs of neurotransmitters, in several neuralnetworks. It will provide a timely overview of a mechanism of neural communication that is likely to attract increasing attention of the neuroscientific community. Addresses the timely topic of co-release of neurotransmitters Will contribute to a change in perspective on this issue in the face of the converging evidence provided by research on completely different systems Should contribute to a re-consideration of this idea in other brain regions INDICE: Mechanisms of synapse formation: Activity-dependent selection of neurotransmitters and receptors.- Regulation of cardiac excitation and inhibition through modulation of sympathetic co-transmission.- The dual glutamatergic/GABAergic phenotype of the hippocampal granule cells.- Glycine-GABA-glutamate co-transmission at developing central auditory synapses.- GABA actions at an excitatory synapse in the hippocampus.- Glutamate co-release by monoamine neurons.- Postsynaptic determinants of inhibitory transmission at mixed GABAergic/glycinergic synapses.- GABA is the main neurotransmitter released from mossy fiber terminals in the developing hippocampus.- The corelease of glutamate and acetylcholine in vertebrate central nervous system.- Co-release of GABA and ATP.- Interactions within Catecholamine Systems: co-release of dopamine and serotonin.- Colocalization and Cotransmission of Classical Neurotransmitters: An Invertebrate Perspective.- Out of many, one: Integration of co-released neurotransmitters.

• ISBN: 978-0-387-09621-6
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 255
• Fecha Publicación: 01/11/2008
• Nº Volúmenes: 1
• Idioma: Inglés