The 40th volume of Methods in Microbiology focuses on microbial synthetic biology. Synthetic biology is a rapidly growing discipline that builds on well-established principles of genetic engineering and biotechnology by integrating computational and engineering approaches to the design and construction of novel biological systems. This volume addresses some of the major technical challenges stand in the way of achieving a radical step-change in our ability to engineer complex multi-scaled biological systems. These include: the application of computation intelligence to the design of synthetic microbial systems, design automation and constraints; the impact of noise and stochasticity; the engineering of biosensors; the characteristic of a model bacterial chassis. A key issue in Synthetic Biology is that of its social dimensions and a chapter is dedicated to the important issue. Authority or expertise of contributors, lLnks to websites for the design and modelling of microbes and microbial metabolism, First volume to address the practical issuesDiscussion on responsible innovation INDICE: Computational Intelligence in the Design of Synthetic Microbial Genetic SystemsJennifer S. HallinanConstraints in the Design of the Synthetic Bacterial ChassisAntoine Danchin and Agnieszka SekowskaSocial Dimensions of Microbial Synthetic BiologyJane Calvert and Emma FrowBacillus Subtilis: Model Gram-positive Synthetic Biology ChassisColin R. Harwood, Suzanne Pohl, Wendy Smith and Anil WipatEngineering Microbial BiosensorsLisa Goers, Nicolas Kylilis, Marios Tomazou, Ke Yan Wen, Paul Freemont and Karen PolizziNoise and Stochasticity in Gene Expression - A Pathogenic Fate determinantMikkel Girke Jørgensen, Renske van Raaphorst and Jan-Willem VeeningPlatforms for Genetic Design AutomationChris J. Myers
- ISBN: 978-0-12-417029-2
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 194
- Fecha Publicación: 29/11/2013
- Nº Volúmenes: 1
- Idioma: Inglés