Pharmaco-complexity: non-linear phenomena and drug product development

The historical approach to the interpretation of physical, chemical and biological phenomena has been to consider relationships with causative factors thatcan be reduced to linearity allowing simple and direct interpretation. However, it is increasingly evident that there is often more information in the datathan linear interpretations allow. The current capacity for computers to assist in identifying non-linear relationships allows greater interpretation of data which illuminates the phenomena allowing the information to be translated into knowledge that can be used wisely to promote various desirable pharmaceutical outcomes. This short volume is intended to stimulate the reader to contemplate research and development areas in which the data might be more accuratelyinterpreted to allow greater understanding and ultimately control of the pharmaceutically complex phenomena. Describes topics that indicate a need for a non-linear interpretation if they are to be characterized accurately, understoodfully and potentially controlled or modulated in the service of improved therapeutic strategies Promotes discussion of phenomena leading to pharmacologicaleffect and the complex interactions ultimately resulting in improved disease control and health maintenance Pocketbook INDICE: The nature of complexity and relevance to the pharmaceutical sciences.- Phenomena in Physical and Surface Chemistry.- Solid State Pharmaceuticals: Solving Complex Problems in Preformulation and Formulation.- Considerationsin monitoring and controlling pharmaceutical manufacturing.- Pharmacokineticsand pharmacodynamics.- Impact of complexity on population Biology.- Conclusion.

• ISBN: 978-1-4419-7855-4
• Editorial: Springer
• Encuadernacion: Rústica
• Páginas: 90
• Fecha Publicación: 28/01/2011
• Nº Volúmenes: 1
• Idioma: Inglés