Replacement Therapies in Adrenal Insufficiency

Replacement Therapies in Adrenal Insufficiency provides a thorough understanding of the conditions which result in adrenal insufficiency. Never before has one source of information combined all updates on current causes and mechanisms of adrenal sufficiency to allow for quick reference and subsequent treatment decisions. Scientific data on this broad condition includes specific disease coverage of Addison's disease, hypopituitarism, congenital adrenal hypoplasia and adrenalectomy. Practical points in diagnosis, dosing, drug interactions, replacement therapies and emergency situations are also provided as guidance for overall management. Provides available treatment means and how to apply them in varying situations, including use among the chronically ill and within emergency settings Includes Clinical Messages within each chapter that provide clinical applications for the latest research in each discipline area, with a specific disease focus Outlines practical points in the management of adrenal insufficiency, including daily maintenance therapy, illness, sick days, emergencies and travel INDICE: 1. Why do we need to get hydrocortisone replacement right?2. Mortality and morbidity data3. Side effects and survey results of quality of life4. Oral Glucocorticoid replacement5. What is dosing regimen6. How to calculate daily dose7. How to distribute the dose8. Drug interactions including drugs that alter liver metabolism9. Specific problems with hormone replacement - oral or transdermal estrogens10. Interplay of cortisol and vasopressin - diagnosis of diabetes insipidus and DDAVP replacement11. Pituitary replacement that may modify hydrocortisone dosing - thyroxine and growth hormone12. Monitoring replacement13. What's missing what are we replacing what should we check14. Ways of checking 17OHP, ACTH cortisol15. Single sample versus multiple samples16. Around dose sampling17. Effects of OCP18. Adjusting doses for events19. Illness and the boxes20. Stressful events21. Surgery22. Dental and the boxes23. Travel and time zones24. Adjustments and effects on other hormones e.g. DDAVP25. Glucocorticoid replacement using pump therapy26. Pump therapy to mimic circadian rhythm27. Principles of the pump28. Setting the system up, clearance studies29. Monitoring replacement30. Quality of life31. Managing an Adrenal Crisis32. Presentation as new diagnosis or following diagnosis33. What it is and what it is not34. Biochemical changes35. How to manage a crisis - at home, in A&E after admission36. Hydrocortisone requirements in a crisis37. Glucose requirements during a crisis38. Sodium and fluid balance - the importance of subacute or chronic hyponatraemia39. Hyperkalaemia40. Weaning Glucocorticoids41. Factors influencing adrenal suppression dose, type of steroid, how long given, potency and whether given during day or night42. The role of alternate day treatments43. Principles in weaning44. How to wean depending on duration of exposure, disease activity steroid used45. What tests to use to determine axis recovery

• ISBN: 978-0-12-824548-4
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 308
• Fecha Publicación: 16/01/2023
• Nº Volúmenes: 1
• Idioma: Inglés