Multiscale Biomechanical Modeling of the Brain

Multiscale Biomechanical Modeling of the Brain discusses the constitutive modeling of the brain at various length scales (nanoscale, microscale, mesoscale, macroscale and structural scale). In each scale, the book describes the state-of-the- experimental and computational tools used to quantify critical deformational information at each length scale. Then, at the structural scale, several user-based constitutive material models are presented, along with real-world boundary value problems. Lastly, design and optimization concepts are presented for use in occupant-centric design frameworks. This book is useful for both academia and industry applications that cover basic science aspects or applied research in head and brain protection.The multiscale approach to this topic is unique, and not found in other books. It includes meticulously selected materials that aim to connect the mechanistic analysis of the brain tissue at size scales ranging from subcellular to organ levels. Presents concepts in a theoretical and thermodynamic framework for each length scale Teaches readers not only how to use an existing multiscale model for each brain but also how to develop a new multiscale model Takes an integrated experimental-computational approach and gives structured multiscale coverage of the problems INDICE: 1. Introduction to multiscale modeling2. Downscaling (Macroscale to nanoscale) multiscale paradigm -Discuss on things related damage/strength, stiffness, vibrations/resonance -Temperature, strain rate and stress state -Fatigue, creep and overloads3. DFT; Electronics for organic molecules4. Nanoscale Atomistics and Molecular Dynamics5. Microscale Mechano-Physiological Modeling and Coarse-Grain Molecular Dynamics6. Mesoscale Finite Element Modeling7. Macroscale Thermodynamic Framework and Modeling8. Structural Scale - Brain's VUmat file calibration, and validation - Blast Finite Element Simulations (high rate) -Blunt Impact Simulations (intermediate rate) - Car Crash Simulations (intermediate rate)9. Robust Multi-objective design and optimization10. Summary and conclusions

• ISBN: 978-0-12-818144-7
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 276
• Fecha Publicación: 02/11/2021
• Nº Volúmenes: 1
• Idioma: Inglés