Joint and Bone: From Bench to Bedside, Volume Three, the latest release in the Stem Cell Innovation in Health and Disease series, is a timely and fascinating collection of information and new discoveries that provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. This new volume addresses the molecular players underlying iPSC formation, maintenance, and expansion and differentiation, bringing chapters that describe cutting-edge research for understanding stem cell functions in joint and bone diseases, and for developing methods to bring stem cells from bench to bedside. Each chapter includes insights ranging from the use of mouse and human organoid cultures, genetic editing in vitro and in vivo, and human iPSCs to study stem cell functions and model joint and bone diseases. Provides cutting-edge research needed to understand stem cell functions in joint and bone diseases Develops processes to bring stem cells from bench to bedside Includes up-to-date references on stem cell biology and function in the joint and bone INDICE: 1. Cutting edge research on stem cell applications in joint and bone repair and regeneration2. Stem Cell-Based Organoid culture system as innovative model of osteoarthritis and other joint/bone diseases3. Contributions of stem cell engineering to new therapies of joint/bone diseases4. Roles of innovative genome editing technologies (e.g. CRISPR/Cas9 systems) in stem cell engineering, rheumatic diseases and other joint/bone diseases5. Preclinical and clinical applications of iPSC technology in modeling osteoarthritis pathologies and testing drugs6. The gold standard iPSCs in cartilage, joint and bone repair and regeneration7. Mesenchymal stem cell related therapies for cartilage, joint and bone diseases8. Advances in animal models for joint and bone diseases9. Novel Biomaterials for stem cell engineering and bone regeneration10. General Discussion, Conclusion Remark and Future Direction
- ISBN: 978-0-323-91938-8
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 200
- Fecha Publicación: 01/09/2022
- Nº Volúmenes: 1
- Idioma: Inglés