Assessing the functional structure of molecular transporters by EPR spectroscopy

In his thesis, Matthias Junk takes an innovative approach to assess the localstructure and dynamics of biological and synthetic amphiphilic macromoleculescapable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure- a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for thematerial’s hosting properties and enable unforeseen complex catalytic functionalities. Nominated by Max-Planck-Institute for Polymer Research, Mainz, Germany Innovative approach to assess the topic Delivers remarkable new insights into materials INDICE: Electron Paramagnetic Resonance Theory. The Functional Structure of Human Serum Albumin. Copper Complexes of Star-Shaped Cholic Acid Oligomers with 1,2,3-Triazole Moieties. Nano-Inhomogeneities in Structure and Reactivity.of Thermoresponsive Hydrogels. Thermoresponsive Spin-Labeled Hydrogels as Separable DNP Polarizing Agents. Local Nanoscopic Heterogeneities in Thermoresponsive Dendronized Polymers. Conclusion. Appendix.

• ISBN: 978-3-642-25134-4
• Editorial: Springer Berlin Heidelberg
• Encuadernacion: Cartoné
• Páginas: 257
• Fecha Publicación: 31/12/2011
• Nº Volúmenes: 1
• Idioma: Inglés