Biochemistry of Collagens, Laminins and Elastin: Structure, Function and Biomarkers

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides a comprehensive introduction to collagen and structural proteinsProvides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradationIncludes a chapter dedicated to the biomarkers of structural proteinsContains insights into the biochemical interactions and changes to structural composition of proteins in disease states INDICE: Why are collagens and structural proteins important? Introduction To The Matrix - Interstitial And Basement Membranes Overall structure of the collagens Collagen Synthesis And Other Essentials TYPE I collagen TYPE II collagen Type III collagen TYPE IV collagen TYPE V collagen Type VI collagen Type VII collagen Type VIII collagen Type IX collagen Type X collagen Type XI collagen Type XII collagen Type XIII collagen Type XIV collagen Type XV collagen Type XVI collagen Type XVII collagen Type XVIII collagen Type XIX collagen Type XX collagen Type XXI collagen Type XXII collagen Type XXIII collagen Type XXIV collagen Type XXV collagen Type XXVI collagen Type XXVII collagen Type XXVIII collagen Laminin LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 LAMC3 Elastin

• ISBN: 978-0-12-809847-9
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 208
• Fecha Publicación: 15/07/2016
• Nº Volúmenes: 1
• Idioma: Inglés