Biochemistry of Collagens, Laminins and Elastin: Structure, Function and Biomarkers

Extended with 8 new chapters and an introduction by Detlef Schuppan, Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, Second Edition provides a completely updated comprehensive new edition of the introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This updated volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signalling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbour cryptic signalling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides a comprehensive introduction to collagen and structural proteinsGives insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradationIncludes eight new chapters including a chapter on how collagen biomarkers are used in clinical research to support drug development and in precision medicineContains insights into the biochemical interactions and changes to structural composition of proteins in disease stateProves the importance of proteins for collagen assembly, function and durability INDICE: 1. Type I Collagen 2. Type II Collagen 3. Type III Collagen 4. Type IV Collagen 5. Type V Collagen 6. Type VI Collagen 7. Type VII Collagen 8. Type VIII Collagen 9. Type IX Collagen 10. Type X Collagen 11. Type XI Collagen 12. Type XII Collagen 13. Type XIII Collagen 14. Type XIV Collagen 15. Type XV Collagen 16. Type XVI Collagen 17. Type XVII Collagen 18. Type XVIII Collagen 19. Type XIX Collagen 20. Type XX Collagen 21. Type XXI Collagen 22. Type XXII Collagen 23. Type XXIII Collagen 24. Type XXIV Collagen 25. Type XXV Collagen 26. Type XXVI Collagen 27. Type XXVII Collagen 28. Type XXVIII Collagen 29. Laminins 30. Elastin 31. Structural Biomarkers

• ISBN: 978-0-12-817068-7
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 416
• Fecha Publicación: 01/05/2019
• Nº Volúmenes: 1
• Idioma: Inglés