Drug metabolism and pharmacokinetics quick guide

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept. Covers a number of aspects of drug assessment at drug discovery and development stages. Includes topics in pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. Covers key concepts, with useful tables on physiological parameters, chemical structure, nomenclature, and moieties leading to bioactivation. INDICE: Pharmacokinetics. Drug Metabolizing Enzymes. Oral Absorption. Transporters. Metabolism-Based Drug Interactions. Biotransformation and Bioactivation. Prediction of Human Pharmacokinetics. Advances in Bioanalysis as it Relates to ADME. ADME Properties and Their Dependence on Physicochemical Properties. In Silico ADME Tools. Approved Drugs. Chemical Nomenclature.

• ISBN: 978-1-4419-5628-6
• Editorial: Springer New York
• Encuadernacion: Rústica
• Páginas: 163
• Fecha Publicación: 29/04/2011
• Nº Volúmenes: 1
• Idioma: Inglés